Horse Serum Butyrylcholinesterase Does Not Disrupt Passive Avoidance Learning...
AbstractRecent advances in the treatment of organophosphorus (OP) toxicity have focussed on the administration of an exogenous cholinesterase (ChE) to act as a scavanger for the OP agent (Doctor, et...
View Article3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") and its...
Abstract.Rationale: The reinforcing effects of MDMA and its enantiomers have not been extensively characterized in laboratory animals. Objectives: To investigate whether MDMA and its stereoisomers...
View ArticlePharmacological characterization of the effects of...
AbstractRationale. Few studies have directly compared the effects of methylenedioxymethamphetamine (MDMA, "ecstasy") and its enantiomers across measures.Objectives. To investigate the capacity of MDMA...
View ArticleNantenine: an antagonist of the behavioral and physiological effects of MDMA...
AbstractRationaleNo selective antagonists for the effects of MDMA have yet been identified. The structurally-similar, naturally-occurring plant alkaloid nantenine (9,10-methylenedioxy-1,2...
View ArticleHallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine...
AbstractRationaleFew studies have examined the effects of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in vivo.Objectives2C-T-7 was tested in a drug-elicited head twitch assay in mice and in...
View ArticleSerotonin synthesis inhibition reveals distinct mechanisms of action for MDMA...
AbstractRationaleDrug challenges in “intact” and p-chlorophenylalanine (p-CPA)-treated animals can be used to distinguish agents that act as direct serotonin (5-HT) agonists from agents that function...
View ArticleReinforcing effects of methylenedioxy amphetamine congeners in rhesus...
AbstractRationaleMany animal models relevant to the persistent effects of drugs of abuse necessitate the application of interspecies dose scaling procedures to approximate drug administration regimens...
View ArticleMDMA use and neurocognition: a meta-analytic review
AbstractRationaleTo determine the association between MDMA misuse and neurocognition using meta-analysis.ObjectiveSeparate analyses were conducted based on two sets of inclusion/exclusion criteria. A...
View ArticleRole of dopamine transporters in the behavioral effects of...
AbstractRationaleThe interoceptive and reinforcing effects of 3,4-methylenedioxymethamphetamine (MDMA) are similar to those of psychostimulants, but the role of dopamine in the behavioral effects of...
View ArticleSynthetic Cannabinoids: Pharmacology, Behavioral Effects, and Abuse Potential
AbstractCannabis has been used throughout the world for centuries. The psychoactive effects of cannabis are largely attributable to ∆9-tetrahydrocannabinol (∆9-THC), the prototypical cannabinoid that...
View ArticlePsychostimulant Abuse and HIV Infection: Cocaine, Methamphetamine, and ‘Bath...
AbstractPsychostimulants are among the most widely-abused substances worldwide, and typically exert their abuse-related effects via interactions with monoamine reuptake transporters within the central...
View ArticlePredisposing effects of neonatal visceral pain on abuse-related effects of...
AbstractRationaleAdverse early life experiences are risk factors for drug abuse and addiction. Changes in brain opioid systems have been demonstrated in response to neonatal visceral pain (NVP), but...
View ArticleHallucinogen-like effects of 2-([2-(4-cyano-2,5-dimethoxyphenyl)...
AbstractRationale2-([2-(4-cyano-2,5-dimethoxyphenyl)ethylamino]methyl)phenol (25CN-NBOH) is structurally similar to N-benzyl substituted phenethylamine hallucinogens currently emerging as drugs of...
View ArticlePharmacological and Toxicological Effects of Synthetic Cannabinoids and Their...
AbstractCommercial preparations containing synthetic cannabinoids (SCBs) are rapidly emerging as drugs of abuse. Although often assumed to be “safe” and “legal” alternatives to cannabis, reports...
View ArticleDiscriminative Stimulus Effects of Psychostimulants
AbstractNumerous drugs elicit locomotor stimulant effects at appropriate doses; however, we typically reserve the term psychostimulant to refer to drugs with affinity for monoamine reuptake...
View ArticleLocomotor effects of 3,4-methylenedioxymethamphetamine (MDMA) and its...
AbstractRationaleThere is a renewed interest in the use of 3,4-methylenedioxymethamphetamine (MDMA) for treating psychiatric conditions. Although MDMA has entered phase II clinical trials and shows...
View ArticleActive vaccination reduces reinforcing effects of MDPV in male Sprague-Dawley...
AbstractRationale3,4-Methylenedioxypyrovalerone (MDPV) is a synthetic cathinone abused for its cocaine-like psychostimulant effects in “bath salts” products. While there are currently no...
View ArticleConvulsant doses of abused synthetic cannabinoid receptor agonists AB-PINACA,...
Abstract RationaleSynthetic cannabinoid receptor agonists (SCRAs) are found in illicit smoking products, such as “K2” or “Spice.” Convulsions are commonly reported adverse effects of SCRAs but are...
View ArticleBehavioral and Neurochemical Consequences of Long-Term Intravenous...
AbstractThe effects of self-administered 3,4-methylenedioxymethamphetamine (MDMA) on behavior and neurochemistry have not been previously studied in laboratory primates. We investigated the capacity of...
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